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Gardenoside (Standard)

CAT: 0804-HY-N1478RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N1478RSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Gardenoside is an orally active natural compound found in Gardenia fruits. Gardenoside reliefs chronic constriction injury (CCI) -induced neuropathic pain by regulating the P2X3 and P2X7 receptors. Gardenoside has an inhibitory effect on free fatty acids (FFA) -induced cellular steatosis. Gardenoside reduces reactive oxygen species (ROS) . Gardenoside can be used for anti-inflammatory, antinociceptive and hepatoprotective study[1][2][3].
CAS Number
24512-62-7
UNSPSC
12352005
Target
P2X Receptor; Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-κB
Field of Research
Inflammation/Immunology; Neurological Disease
Smiles
O=C(C1=CO[C@@H](O[C@H]2[C@@H]([C@H]([C@@H]([C@@H](CO)O2)O)O)O)[C@@]3([H])[C@]1([H])C=C[C@@]3(O)CO)OC
Molecular Formula
C17H24O11
Molecular Weight
404.37
References & Citations
[1]Yu M, Su B, et al. Gardenoside suppresses the pain in rats model of chronic constriction injury by regulating the P2X3 and P2X7 receptors. J Recept Signal Transduct Res. 2018 Jun;38 (3) :198-203.|[2]Liang H, et al. Inhibitory Effect of Gardenoside on Free Fatty Acid-Induced Steatosis in HepG2 Hepatocytes. Int J Mol Sci. 2015 Nov 20;16 (11) :27749-56.|[3]Xia T, et al. Gardenoside ameliorates inflammation and inhibits ECM degradation in IL-1β-treated rat chondrocytes via suppressing NF-κB signaling pathways. Biochem Biophys Res Commun. 2023 Jan 15;640:164-172.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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