Sennoside

• Description :

  Sennoside is an orally active anthraquinone glycoside that can be used as a stimulant laxative. Sennoside exerts prokinetic and secretory effects via activation of 5-HT4 receptors in the myenteric plexus and inhibition of Na+/K+-ATPase activity. Sennoside is promising for research of chronic constipation[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H317-H334

• Target :

  5-HT Receptor; Na+/K+ ATPase

• Related Pathways :

  GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Smiles :

  OC[C@@H](O1)[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1OC2=CC=CC3=C2C(C4=C(C=C(C(O)=O)C=C4O)C3C5C6=C(C(C7=C5C=C(C(O)=O)C=C7O)=O)C(O[C@H]8[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O8)=CC=C6)=O

• Molecular Formula :

  C42H38O20

• Molecular Weight :

  862.74

• Precautions :

  P261-P272-P280-P284-P302+P352-P304+P340-P362+P364-P501

• References & Citations :

  [1]Rama Reddy NR, et al. Next Generation Sequencing and Transcriptome Analysis Predicts Biosynthetic Pathway of Sennosides from Senna (Cassia angustifolia Vahl.), a Non-Model Plant with Potent Laxative Properties. PLoS One. 2015 Jun 22;10 (6) :e0129422.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  Phase 2

• CAS Number :

  [517-43-1]