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Petasin

CAT: 0804-HY-N10612Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N10612Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Petasin inhibits adipogenesis in cell 3T3-F442A with an IC50 of 0.95 μM. Petasin inhibits the expression of lipid synthesis factors ACC1, FAS and SCD1 by inhibiting transcription factors PPARγ and C/EBPα, as well as targeting TRPA1 and TRPV1 channels . Petasin inhibits mitochondrial complex I, thereby inhibiting tumor growth and metastasis. Petasin activates AMPK signaling pathway, participating in regulation of glucose and lipid metabolism. Petasin is orally active[1].
CAS Number
26577-85-5
UNSPSC
12352211
Target
AMPK; Mitochondrial Metabolism; PPAR; TRP Channel
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling; PI3K/Akt/mTOR; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer; Metabolic Disease
Smiles
C[C@@]12C(CC[C@H]([C@@H]2C)OC(/C(C)=C\C)=O)=CC([C@@H](C1)C(C)=C)=O
Molecular Formula
C20H28O3
Molecular Weight
316.43
References & Citations
[1]Uesugi S, et al., Petasin is the main component responsible for the anti-adipogenic effect of Petasites japonicus. Fitoterapia. 2022 Mar;157:105130.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported

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