Allantoic acid (Standard)

• Description:

  Anagrelide (hydrochloride) (Standard) is the analytical standard of Anagrelide (hydrochloride) . This product is intended for research and analytical applications. Anagrelide hydrochloride (BL4162A) is a potent inhibitor of phosphodiesterase type III (PDE3) (IC50=36 nM) . Anagrelide hydrochloride, an imidazoquinazoline derivative, acts as an inhibitor of platelet aggregation. Anagrelide hydrochloride inhibits bone marrow megakaryocytopoiesis. Anagrelide hydrochloride decreases gastrointestinal stromal tumor (GIST) cell proliferation and promotes their apoptosis in vitro. Anagrelide hydrochloride is a platelet-lowering agent and plays in the antithrombopoietic action[1][2][3].

• UNSPSC:

  12352211

• Hazard Statement:

  H315, H319, H335

• Target:

  Endogenous Metabolite; Reference Standards

• Related Pathways:

  Metabolic Enzyme/Protease; Others

• Field of Research:

  Others

• Purity:

  99.84

• Smiles:

  NC(NC(C(O)=O)NC(N)=O)=O

• Molecular Formula:

  C4H8N4O4

• Molecular Weight:

  176.13

• Precautions:

  H315, H319, H335

• References & Citations:

  [1]Taherkhani A, et, al. Metabolomic Analysis of Membranous Glomerulonephritis: Identification of a Diagnostic Panel and Pathogenic Pathways. Arch Med Res. 2019 May; 50 (4) :159-169.|[2]Okumura I, et, al. Stereospecificity of conversion of uric acid into allantoic acid by enzymes of Canadida utilis. J Biochem. 1976 May;79 (5) :1013-9.|[3]Cai HL, et, al. Therapeutic efficacy of atypical antipsychotic drugs by targeting multiple stress-related metabolic pathways. Transl Psychiatry. 2017 May 16; 7 (5) :e1130.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  4°C, sealed storage, away from light and moisture

• Scientific Category:

  Reference Standards

• CAS Number:

  99-16-1