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Efaroxan

CAT: 0804-HY-B1416Size: 1 EachDry Ice: NoHazardous: No
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Description
Efaroxan is a potent, selective and orally active α2-adrenoceptor antagonist, with antidiabetic activity. Efaroxan is a selective I1-Imidazoline receptor antagonist. Efaroxan can be used for the research of cardiovascular disease[1][2][3].
CAS Number
89197-32-0
UNSPSC
12352005
Target
Adrenergic Receptor; Imidazoline Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Cardiovascular Disease; Metabolic Disease
Smiles
CCC1(C2=NCCN2)OC3=CC=CC=C3C1
Molecular Formula
C13H16N2O
Molecular Weight
216.28
References & Citations
[1]Berridge TL, et al. Selectivity profile of the alpha 2-adrenoceptor antagonist efaroxan in relation to plasma glucose and insulin levels in the rat. Eur J Pharmacol. 1992 Mar 24;213 (2) :205-12. |[2]A O Abdel-Zaher, et al. The potential antidiabetic activity of some alpha-2 adrenoceptor antagonists. Pharmacol Res. 2001 Nov;44 (5) :397-409.|[3]T L Berridge, et al. Comparison of the effects of efaroxan and glibenclamide on plasma glucose and insulin levels in rats. Eur J Pharmacol. 1992 Mar 24;213 (2) :213-8.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Efaroxan

2-(2-ethyl-3H-benzofuran-2-yl)-4,5-dihydro-1H-imidazole is a member of 1-benzofurans.

CAS Number89197-32-0
PubChem CID72016
IUPAC Name2-(2-ethyl-3H-1-benzofuran-2-yl)-4,5-dihydro-1H-imidazole
Molecular FormulaC13H16N2O
Molecular Weight216.28
XLogP1.7
Topological Polar Surface Area33.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Heavy Atom Count16
Formal Charge0
Complexity302
SMILES
CCC1(CC2=CC=CC=C2O1)C3=NCCN3
InChI
InChI=1S/C13H16N2O/c1-2-13(12-14-7-8-15-12)9-10-5-3-4-6-11(10)16-13/h3-6H,2,7-9H2,1H3,(H,14,15)
InChIKey
RATZLMXRALDSJW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Efaroxan
CAS: 89197-32-0
CID: 72016
Formula: C13H16N2O
MW: 216.28
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight216.28
XLogP31.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count2
Exact Mass216.126263138
Monoisotopic Mass216.126263138
Topological Polar Surface Area33.6 Ų
Heavy Atom Count16
Formal Charge0
Complexity302
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
GTR19273875-01Efaroxan
540114Efaroxan HCl
sc-203573Efaroxan hydrochloride
TBI1342-250MGEfaroxan HCl, a2 adrenergic antagonist

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