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Spiperone (Standard)

CAT: 0804-HY-B1371R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-B1371R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Spiperone (Standard) is the analytical standard of Spiperone. This product is intended for research and analytical applications. Spiperone (Spiroperidol) is a potent dopamine D2, serotonin 5-HT1A, and serotonin 5-HT2A antagonist. Spiperone is also a labelled ligand for neuroleptic receptors. Spiperone enhances intracellular calcium level and inhibits the Wnt signaling pathway. Spiperone has the potential for the research of neurology diseases[1][2][3][4].
CAS Number
749-02-0
UNSPSC
12352100
Target
5-HT Receptor; Dopamine Receptor; Reference Standards; Wnt
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others; Stem Cell/Wnt
Field of Research
Neurological Disease
Smiles
O=C1NCN(C2=CC=CC=C2)C13CCN(CCCC(C4=CC=C(F)C=C4)=O)CC3
Molecular Formula
C23H26FN3O2
Molecular Weight
395.47
References & Citations
[1]Metwally KA, et al. Spiperone: influence of spiro ring substituents on 5-HT2A serotonin receptor binding. J Med Chem. 1998;41 (25) :5084-5093.|[2]Palacios JM, et al. [3H]Spiperone binding sites in brain: autoradiographic localization of multiple receptors. Brain Res. 1981 Jun 1;213 (2) :277-89.|[3]Leysen JE, et al. Spiperone: a ligand of choice for neuroleptic receptors. 1. Kinetics and characteristics of in vitro binding. Biochem Pharmacol. 1978 Feb 1;27 (3) :307-16. |[4]Lu D, et al. Spiperone enhances intracellular calcium level and inhibits the Wnt signaling pathway. BMC Pharmacol. 2009 Nov 30;9:13.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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