Tetramisole

CAT: 0804-HY-B1194ASize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-B1194ASize:1 Each
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Description
Tetramisole is an orally active, selective inward rectifier potassium channel agonist with an EC50 of approximately 30 μM for the Kir2.1 subunit. Tetramisole is also an anti-nematode agent that blocks neuromuscular transmission by non-competitive depolarization. Tetramisole promotes the forward transport of Kir2.1 channels, hyperpolarizes the resting potential (RP), shortens the action potential duration (APD), inhibits intracellular calcium overload and the PKA signaling pathway, and exerts anti-arrhythmic and anti-myocardial remodeling activities. Tetramisole can be used in cardiac electrophysiology research and research related to myocardial ischemia and heart failure[1][2].
CAS Number
[5036-02-2]
UNSPSC
12352005
Target
Parasite; PKA; Potassium Channel
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel; Stem Cell/Wnt; TGF-beta/Smad
Applications
Neuroscience-Neuromodulation
Field of Research
Infection; Cardiovascular Disease
Smiles
C12=NC(C3=CC=CC=C3)CN1CCS2
Molecular Formula
C11H12N2S
Molecular Weight
204.29
References & Citations
[1]Liu Q, et al. Tetramisole is a new IK1 channel agonist and exerts IK1 -dependent cardioprotective effects in rats. Pharmacol Res Perspect. 2022 Aug;10 (4) :e00992.|[2]Nowak LG, et al. Tetramisole and Levamisole Suppress Neuronal Activity Independently from Their Inhibitory Action on Tissue Non-specific Alkaline Phosphatase in Mouse Cortex. Subcell Biochem. 2015;76:239-81.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
Inwardly rectifying potassium channel

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