Itopride-d6

• Description:

  Itopride-d6 (HSR803-d6 (free base) ) is deuterium labeled Itopride. Itopride (HSR803 free base) is a potent and orally active dopamine-2 antagonist and an acetylcholine esterase (AChE) inhibitor. Itopride enhances gastric motility through both antidopaminergic and anti-acetylcholinesterasic actions, can be used as a gastrointestinal prokinetic agent. Itopride can be used for researching gastro-esophageal reflux disease (GERD) [1].

• Product Name Alternative:

  HSR803-d6 (free base)

• UNSPSC:

  12352005

• Target:

  Bacterial; Cholinesterase (ChE) ; Dopamine Receptor; Isotope-Labeled Compounds

• Related Pathways:

  Anti-infection; GPCR/G Protein; Neuronal Signaling; Others

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Others

• Smiles:

  [2H]C ([2H]) ([2H]) N (C ([2H]) ([2H]) [2H]) CCOC (C=C1) =CC=C1CNC (C2=CC (OC) =C (C=C2) OC) =O

• Molecular Formula:

  C20H20D6N2O4

• Molecular Weight:

  364.47

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Iwanaga Y, et al. A novel water-soluble dopamine-2 antagonist with anticholinesterase activity in gastrointestinal motor activity. Comparison with domperidone and neostigmine. Gastroenterology. 1990 Aug;99 (2) :401-8.|[3]Kim YS, et al. Effect of itopride, a new prokinetic, in patients with mild GERD: a pilot study. World J Gastroenterol. 2005 Jul 21;11 (27) :4210-4.|[4]Hyun Chul Lim, et al. Effect of Itopride Hydrochloride on the Ileal and Colonic Motility in Guinea Pig In Vitro. Effect of Itopride Hydrochloride on the Ileal and Colonic Motility in Guinea Pig In Vitro. Yonsei Med J. 2008 Jun 30;49 (3) :472-8.|[5]Kenjiro Matsumoto, et al. Validation of 13 C-Acetic Acid Breath Test by Measuring Effects of Loperamide, Morphine, Mosapride, and Itopride on Gastric Emptying in Mice. Biol Pharm Bull. 2008 Oct;31 (10) :1917-22.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  1346746-82-4