(+) -Tetrabenazine

CAT: 0804-HY-B0590B-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-B0590B-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(+) -Tetrabenazine ((+) -TBZ; (3R,11bR) -TBZ; (3R,11bR) -Tetrabenazine) is a reversible inhibitor of vesicular monoamine transporter 2 (VMAT-2), inhibits transport by VMAT2 with 10-fold greater potency than transport by VMAT1. target: VMAT-2 In vitro: (+) -Tetrabenazine inhibit the activity of the transporter but appear to interact differently with the protein. [2] (+) -Tetrabenazine inhibits reserpine binding to the transporter, suggesting that the sites may interact in an allosteric manner. [1] In vivo: 0.9% saline (80%) and dimethylsulfoxide (DMSO) (20%) . (+) -Tetrabenazine blocks dopamine (DA) storage and depletes striatal DA; (+) -Tetrabenazine was shown to induce tremulous jaw movements (TJMs) in rats and mice. The reference dose for administration is 2.0 mg/kg.[2]
CAS Number
[1026016-83-0]
Product Name Alternative
(+) -TBZ; (3R,11bR) -TBZ; (3R,11bR) -Tetrabenazine
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Monoamine Transporter
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
98.72
Solubility
DMSO : 16.67 mg/mL (ultrasonic)
Smiles
COC1=C(OC)C=C(CCN(C[C@H]2CC(C)C)[C@]3([H])CC2=O)C3=C1
Molecular Formula
C19H27NO3
Molecular Weight
317.42
Precautions
H315, H319, H320
References & Citations
[1]Podurgiel SJ et al. The MAO-B inhibitor deprenyl reduces the oral tremor and the dopamine depletion induced by the VMAT-2 inhibitor tetrabenazine. Behav Brain Res. 2016 Feb 1;298 (Pt B) :188-91.|[2]Peter D et al. Chimeric vesicular monoamine transporters identify structural domains that influence substrate affinity and sensitivity to tetrabenazine. J Biol Chem. 1996 Feb 9;271 (6) :2979-86.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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