Prednisone-13C2, d2

• Description:

  Prednisone-13C2, d2 (Dehydrocortisone-13C2, d2) is 13C labeled Prednisone. Prednisone (Adasone) is a corticosteroid agent with anti-inflammatory and immunosuppressive effects that can be used to study diseases related to systemic lupus erythematosus[1][2].

• Product Name Alternative:

  Dehydrocortisone-13C2, d2

• UNSPSC:

  12352211

• Target:

  Apoptosis; Glucocorticoid Receptor; Isotope-Labeled Compounds

• Related Pathways:

  Apoptosis; Immunology/Inflammation; Others; Vitamin D Related/Nuclear Receptor

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Inflammation/Immunology; Endocrinology; Cancer; Cardiovascular Disease

• Smiles:

  C[C@@]12[C@] (CC ([2H]) ([2H]) [C@]2 (O) [13C] ([13CH2]O) =O) ([H]) [C@@]3 ([H]) [C@@] (C (C1) =O) ([H]) [C@@]4 (C (CC3) =CC (C=C4) =O) C

• Molecular Formula:

  C19 13C2H24D2O5

• Molecular Weight:

  362.43

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]RIEMER AD. Application of the newer corticosteroids to augment diuresis in congestive heart failure. Am J Cardiol. 1958 Apr;1 (4) :488-96.|[3][2]N Tomioka, et al. Effects of prednisolone on acute viral myocarditis in mice. J Am Coll Cardiol. 1986 Apr;7 (4) :868-72.|[4]Qianqian Li, et al. Metabolic Profiling Reveals an Abnormal Pattern of Serum Fatty Acids in MRL/lpr Mice Under Treatment With Prednisone. Front Pharmacol. 2020 Feb 25;11:115.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported