Fluoxetine-d6

• Description:

  Fluoxetine-d6 (LY-110140 (free base) -d6) is deuterium labeled Fluoxetine. Fluoxetine (LY-110140 free base) is a selective serotonin reuptake inhibitor (SSRI) class used for antidepressant research.

• Product Name Alternative:

  LY-110140 (free base) -d6

• UNSPSC:

  12352005

• Target:

  Autophagy; Isotope-Labeled Compounds; Serotonin Transporter

• Related Pathways:

  Autophagy; Neuronal Signaling; Others

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Smiles:

  FC (F) (F) C (C=C1) =CC=C1OC (C2=C ([2H]) C ([2H]) =C ([2H]) C ([2H]) =C2[2H]) ([2H]) CCNC

• Molecular Formula:

  C17H12D6F3NO

• Molecular Weight:

  315.36

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Bymaster FP, et al. Fluoxetine, but not other selective serotonin uptake inhibitors, increases norepinephrine and dopamine extracellular levels in prefrontal cortex. Psychopharmacology (Berl) . 2002 Apr;160 (4) :353-61|[3]Zhang W, et al. Synergistic effects of olanzapine and other antipsychotic agents in combination with fluoxetine on norepinephrine and dopamine release in rat prefrontal cortex. Neuropsychopharmacology. 2000 Sep;23 (3) :250-62.|[4]Wang JW, et al. Chronic fluoxetine stimulates maturation and synaptic plasticity of adult-born hippocampal granule cells. J Neurosci. 2008 Feb 6;28 (6) :1374-84.|[5]Avitsur R1. Increased symptoms of illness following prenatal stress: Can it be prevented by fluoxetine? Behav Brain Res. 2017 Jan 15;317:62-70.|[6]Kodama M, et al. Chronic olanzapine or fluoxetine administration increases cell proliferation in hippocampus and prefrontal cortex of adult rat. Biol Psychiatry. 2004 Oct 15;56 (8) :570-80.|[7]Malberg JE, et al. Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacology. 2003 Sep;28 (9) :1562-71

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  2319722-07-9