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Forasartan

CAT: 0804-HY-A0224Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-A0224Size:1 Each
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Description
Forasartan is an nonpeptide angiotensin AT1 receptor antagonist with an IC50 of 2.9 nM. Forasartan is also an anti-hypertension agent. Forasartan significantly inhibits preganglionic stimulation in a dose-dependent manner in vivo. Forasartan can inhibit the heart rate increase induced by angiotensin II[1][2][3].
CAS Number
145216-43-9
Product Name Alternative
SC-52458
UNSPSC
12352005
Target
Angiotensin Receptor
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Smiles
CCCCC1=NC(CCCC)=NN1CC2=CN=C(C3=CC=CC=C3C4=NNN=N4)C=C2
Molecular Formula
C23H28N8
Molecular Weight
416.52
References & Citations
[1]Tokunaga, R., et al., (2001) . Possible involvement of calcium-calmodulin pathways in the positive chronotropic response to angiotensin II on the canine cardiac sympathetic ganglia. Japanese journal of pharmacology, 86 (4), 381-389.|[2]Gul, F., Parvaiz, N., & Azam, S. S. (2023) . Deciphering the relational dynamics of AF-2 domain of PAN PPAR through drug repurposing and comparative simulations. PloS one, 18 (3), e0283743.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
AR-F09369-01Forasartan

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