Malotilate (Standard)

CAT: 0804-HY-A0060R-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-A0060R-01Size:5 mg
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Description
Malotilate (Standard) is the analytical standard of Malotilate. This product is intended for research and analytical applications. Malotilate (NKK 105), an orally active hepatotropic agent and an anti-fibrotic substance, selectively inhibits the 5-lipoxygenase (5-LOX) (IC50=4.7 μM) . Malotilate prevents the development of hepatocytic injury in alcohol-pyrazole hepatitis by decreasing hepatic acetaldehyde levels and preventing the retention of transferrin in the hepatocytes[1][2].
CAS Number
[59937-28-9]
UNSPSC
12352100
Target
Lipoxygenase; Reference Standards
Related Pathways
Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Smiles
O=C(OC(C)C)/C(C(OC(C)C)=O)=C1SC=CS\1
Molecular Formula
C12H16O4S2
Molecular Weight
288.38
References & Citations
[1]Matsuda Y, et al. Effects of malotilate on alcoholic liver injury in rats. Alcohol Clin Exp Res. 1988;12 (5) :665-670.|[2]Vermeer MA, Wilson JH, Zijlstra FJ, Vincent JE. Differential effects of malotilate on 5-, 12- and 15-lipoxygenase in human ascites cells. Agents Actions. 1989;26 (1-2) :252-253.|[3]Poeschl A, et al. Malotilate reduces collagen synthesis and cell migration activity of fibroblasts in vitro. Biochem Pharmacol. 1987;36 (22) :3957-3963.|[4]Zijlstra FJ, et al. Differential effects of malotilate on 5-, 12- and 15-lipoxygenase in human ascites cells. Eur J Pharmacol. 1989;159 (3) :291-295.|[5]Wakasugi J, et al. Action of malotilate on reduced serum cholesterol level in rats with carbon tetrachloride-induced liver damage. Jpn J Pharmacol. 1985;38 (4) :391-401.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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abx282833-01Malotilate
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A10552-50Malotilate 50mg
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