Boc3Arg

CAT: 0804-HY-23020-01Size: 500 mgDry Ice: NoHazardous: No

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CAT#:0804-HY-23020-01Size:500 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

Boc3Arg is the tert-butyl carbamate-protected arginine. Boc3Arg is an efficient tag to induce degradation through directly localizing the protein to the 20S proteasome[1][2].

CAS Number

108787-91-3

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Proteasome

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Purity

97.0

Solubility

DMSO : ≥ 200 mg/mL

Smiles

O=C(O)[C@H](CCC/N=C(NC(OC(C)(C)C)=O)/NC(OC(C)(C)C)=O)NC(OC(C)(C)C)=O

Molecular Formula

C21H38N4O8

Molecular Weight

474.55

Precautions

H302, H315, H319, H335

References & Citations

[1]Sun H, et al. Identification of Boc2Lys-Linked Ethacrynic Acid and Its Analogues As Efficient Glutathione S-Transferase Degraders. ACS Med Chem Lett. 2024 Oct 14;15 (11) :1852-1859.|[2]Marcus J.C. Long, et al. Inhibitor Mediated Protein Degradation. Chemistry & Biology. 2021, 19 (5) : 629-637.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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