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Telomerase-IN-8

CAT: 0804-HY-204056Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-204056Size:1 Each
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Description
Telomerase-IN-8 is an orally active telomerase inhibitor, with an IC50 value of 0.98 μM. Telomerase-IN-8 exhibits potent antiproliferative activity against multiple tumor cell lines, including PC3, Bcap-37, MGC-803 and HepG2. Telomerase-IN-8 demonstrates potent antitumor efficacy in S180 sarcoma or HepG2 hepatoma xenograft mice. Telomerase-IN-8 can be used for the study of telomerase-targeted anticancer[1].
CAS Number
1884341-01-8
UNSPSC
12352005
Target
Telomerase
Related Pathways
Cell Cycle/DNA Damage
Field of Research
Cancer
Smiles
O=C1OC2=C(C=C1C3=NN(C(C3)C4=CC=CC=C4)C(CN(CCCC)CCCC)=O)C=CC=C2
Molecular Formula
C28H33N3O3
Molecular Weight
459.58
References & Citations
[1]Wang Y, et al. Dihydropyrazole derivatives as telomerase inhibitors: Structure-based design, synthesis, SAR and anticancer evaluation in vitro and in vivo. Eur J Med Chem. 2016 Apr 13;112:231-251.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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