DY-9760e

CAT: 0804-HY-19230Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-19230Size:1 Each
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
DY-9760e is a calmodulin (CaM) inhibitor. DY-9760e selectively inhibits the activity of various calmodulin-dependent enzymes by antagonizing the Ca²⁺/CaM complex, exhibiting the strongest inhibitory activity against nNOS, CaM kinase II, and calcineurin (Ki: 0.9, 1.4, and 2.0 μM, respectively) . DY-9760e inhibits excessive nitric oxide production and protein tyrosine nitration, as well as the activation of calpain and caspase-3. DY-9760e reduces infarct size, improves cardiac function, and inhibits oxidative stress and cell death. DY-9760e can be used in research on the treatment of myocardial infarction, cerebral ischemia, and other diseases[1].
CAS Number
[179185-73-0]
UNSPSC
12352005
Target
Calcineurin; Calmodulin; CaMK; Caspase; NO Synthase; Proteasome
Related Pathways
Apoptosis; Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Cardiovascular Disease
Smiles
ClC1=CC=CC(N2CCN(CC2)CCC3=NN(CC4=CN=CN4)C5=C3C=C(OC)C(OC)=C5)=C1C.Cl.[7/2H2O].Cl
Molecular Formula
C26H31ClN6O2.2ClH.7/2H2O
Molecular Weight
630.50
References & Citations
[1]Fukunaga K, et al. DY-9760e, a novel calmodulin inhibitor, exhibits cardioprotective effects in the ischemic heart. Cardiovasc Drug Rev. 2006 Summer;24 (2) :88-100.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CaMK II; Caspase 3; nNOS

Related Products

CatalogName
HY-151136-01DY-46-2
HY-D2761DY-680-NHS ester

Alternative Products

CatalogName
MBS3607683-01DY-131
523119DY-268
447755DY 268
MBS132672-01DY 131
MBS8246436-01dY-V-G
M35659-01DY-46-2
sc-221572ADY-630-avidin
sc-221567ADY-550-avidin
A16077-1DY 268 1mg
A16077-10DY 268 10mg

Popular Products