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Type-II-IN-1

CAT: 0804-HY-18911Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-18911Size:1 Each
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Description
Type-II-IN-1 (Compound 3) is a type II spleen tyrosine kinase (Syk) inhibitor with an IC50 of 2.1 nM. Type-II-IN-1 can bind to the DFG-out conformation of Syk. Type-II-IN-1 can be used for the research of immunology, such as asthma[1].
CAS Number
1419299-81-2
UNSPSC
12352005
Target
Syk
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Inflammation/Immunology
Smiles
O=C(C1=CC=CC(C(F)(F)F)=C1)NC2=CC=C(C)C(C3=CC4=C(N(C)C3=O)N=C(NC5=CC=CC=C5)N=C4)=C2
Molecular Formula
C29H22F3N5O2
Molecular Weight
529.51
References & Citations
[1]Lovering F, et al. Identification of type-II inhibitors using kinase structures[J]. Chemical biology & drug design, 2012, 80 (5) : 657-664.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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