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Mozavaptan (Standard)

CAT: 0804-HY-18346R-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-18346R-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Mozavaptan (Standard) is the analytical standard of Mozavaptan. This product is intended for research and analytical applications. Mozavaptan (OPC-31260) is a benzazepine derivative and a potent, selective, competitive and orally active vasopressin V2 receptor antagonist with an IC50 of 14 nM. Mozavaptan shows ~85-fold selectivity for V2 receptor over V1 receptor (IC50 of 1.2 μM), and can antagonize the antidiuretic action of arginine vasopressin (AVP) in vivo. Mozavaptan has the potential for hyponatremia, syndrome of inappropriate antidiuretic hormone (SIADH), and congestive heart failure treatment[1][2].
CAS Number
137975-06-5
UNSPSC
12352100
Target
Reference Standards; Vasopressin Receptor
Related Pathways
GPCR/G Protein; Others
Field of Research
Cancer; Endocrinology; Metabolic Disease; Cardiovascular Disease
Smiles
CC1=CC=CC=C1C(NC2=CC=C(C(N3C(C=CC=C4)=C4C(N(C)C)CCC3)=O)C=C2)=O
Molecular Formula
C27H29N3O2
Molecular Weight
427.54
References & Citations
[1]Yamamura Y, et al. Characterization of a novel aquaretic agent, OPC-31260, as an orally effective, nonpeptide vasopressin V2 receptor antagonist. Br J Pharmacol. 1992 Apr;105 (4) :787-91.|[2]Yamaguchi K, et al. Clinical implication of the antidiuretic hormone (ADH) receptor antagonist mozavaptan hydrochloride in patients with ectopic ADH syndrome. Jpn J Clin Oncol. 2011 Jan;41 (1) :148-52.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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