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Nitromemantine

CAT: 0804-HY-180370Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-180370Size:1 Each
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Description
Nitromemantine is a nitrate derivative of Memantine and is a dual-functional NMDAR antagonist. Nitromemantine exhibits significant efficacy in rodent models of cerebral infarction through a dual mechanism of blocking channels and regulating receptors via NO/redox regulation. Nitromemantine can target ischemic neurons under hypoxic conditions and enhance its activity. Nitromemantine inhibits the current induced by NMDA, with its IC50 being 2.4 μM. Nitromemantine can be used for the study of cerebral ischemic stroke[1].
CAS Number
765890-91-3
UNSPSC
12352211
Target
Drug Derivative; iGluR
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling; Others
Field of Research
Cardiovascular Disease; Neurological Disease
Smiles
CCC1(C2)CC3(CC)CC2(N)CC(C3)(O[N+]([O-])=O)C1
Molecular Formula
C14H24N2O3
Molecular Weight
268.35
References & Citations
[1]Takahashi H, et al. Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease. Sci Rep. 2015 Oct 19;5:14781.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
GTR19274120-01Nitromemantine

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