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Graviquinone

CAT: 0804-HY-180357Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-180357Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Graviquinone is a Chk1 inhibitor. Graviquinone exhibits potent cytotoxicity against various cancer cell lines. Graviquinone possesses the characteristics of bypassing ABCB1-mediated multidrug resistance, selectively damaging cancer cell DNA, and regulating the DNA damage response. Graviquinone can also enhance cytotoxicity by increasing ROS levels in cancer cells. Graviquinone can be used for cancer research[1].
CAS Number
1383995-51-4
UNSPSC
12352211
Target
Checkpoint Kinase (Chk) ; Reactive Oxygen Species (ROS)
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Cancer
Smiles
COC(/C=C/C1(C=CC(C=C1)=O)O)=O
Molecular Formula
C10H10O4
Molecular Weight
194.18
References & Citations
[1]Fási L, et al. Antioxidant-Inspired Drug Discovery: Antitumor Metabolite Is Formed in Situ from a Hydroxycinnamic Acid Derivative upon Free-Radical Scavenging. J Med Chem. 2019 Feb 14;62 (3) :1657-1668.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
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