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WZS0347

CAT: 0804-HY-179717-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-179717-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
WZS0347 is a MITF PROTAC degrader. WZS0347 effectively reduces the MITF protein levels in several melanoma cell lines, including B16F10, A375, and GAK. WZS0347 significantly inhibits the proliferation, migration, and invasion of melanoma cells. WZS0347 can be used for research on melanoma (Pink: MITF ligand: ; Blue: CRBN ligand: (HY-131717) ; Black: linker: (HY-22391) ).
UNSPSC
12352005
Target
Microphthalmia Associated Transcription Factor (MITF) ; PROTACs
Related Pathways
Cell Cycle/DNA Damage; PROTAC
Field of Research
Cancer
Smiles
O=C(NCCCCCCCNC1=CC(NC(/C=C/C2=CC=CO2)=O)=NC(NC(/C=C/C3=CC=CO3)=O)=C1)CNC4=CC=CC(C(N5C(CC6)C(NC6=O)=O)=O)=C4C5=O
Molecular Formula
C41H42N8O9
Molecular Weight
790.82
References & Citations
[1]Shen W, et al. Discovery of a first-in-class degrader for microphthalmia-associated transcription factor (MITF) . Eur J Med Chem. 2026 Jan 15;302 (Pt 3) :118367.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon

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