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VS3

CAT: 0804-HY-179706Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179706Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VS3 is a YAP-TEAD interaction inhibitor. VS3 directly disrupts the interaction between YAP-TEAD by binding to TEAD4 Interface 3 (Kd = 6 μM) on the surface. VS3 exhibits anti-proliferative activity against HT29, HCT116, and A2780. VS3 can be used for research on colorectal adenocarcinoma and ovarian cancer[1].
CAS Number
2576427-49-9
UNSPSC
12352005
Target
YAP
Related Pathways
Stem Cell/Wnt
Field of Research
Cancer
Smiles
CC1=CC=CC=C1COC2=CC=C(C3C(C=NN4)=C4NC(C3)=O)C=C2OC
Molecular Formula
C21H21N3O3
Molecular Weight
363.41
References & Citations
[1]Scalvini L, et al. Identification of pyrazolo-piperidinone derivatives targeting YAP-TEAD interface 3 as anticancer agents through integrated virtual screening and mass spectrometry proteomics. Eur J Med Chem. 2025 Dec 15;300:118056.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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