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ST13

CAT: 0804-HY-179654Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179654Size:1 Each
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Description
ST13, an ortho-hydroxyanilide, is a selective, slow- and tight-binding HDAC1 and HDAC2 inhibitor with IC50s of 23 nM and 49 nM, respectively. ST13 shows a weak inhibition of HDAC3 (IC50 = 4.30 μM) and HDAC6 (IC50 > 10 μM) . The induced fit mechanism of ST13 proceeds through a two-step process: first, the enzyme and inhibitor rapidly form a collision complex (EI), which then slowly transforms into the stable complex E*I. ST13 induces apoptosis in cancer cells. ST13 can be used for the study of melanoma and triple-negative breast[1].
CAS Number
1013620-98-8
UNSPSC
12352005
Target
Apoptosis; HDAC
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
CC(NC1=CC=C(C(NC2=C(O)C=CC(C3=CC=CC=C3)=C2)=O)C=C1)=O
Molecular Formula
C21H18N2O3
Molecular Weight
346.38
References & Citations
[1]Honin I, et al. Ortho-Hydroxyanilides: Slow-Acting, Selective Histone Deacetylase 1/2 Inhibitors Suitable for Photocaging Applications. ACS Pharmacol Transl Sci. 2025;8 (12) :4385-4398. 
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC2; HDAC3; HDAC6

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