ST13

• Description :

  ST13, an ortho-hydroxyanilide, is a selective, slow- and tight-binding HDAC1 and HDAC2 inhibitor with IC50s of 23 nM and 49 nM, respectively. ST13 shows a weak inhibition of HDAC3 (IC50 = 4.30 μM) and HDAC6 (IC50 > 10 μM) . The induced fit mechanism of ST13 proceeds through a two-step process: first, the enzyme and inhibitor rapidly form a collision complex (EI), which then slowly transforms into the stable complex E*I. ST13 induces apoptosis in cancer cells. ST13 can be used for the study of melanoma and triple-negative breast[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; HDAC

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage; Epigenetics

• Field of Research :

  Cancer

• Smiles :

  CC(NC1=CC=C(C(NC2=C(O)C=CC(C3=CC=CC=C3)=C2)=O)C=C1)=O

• Molecular Formula :

  C21H18N2O3

• Molecular Weight :

  346.38

• References & Citations :

  [1]Honin I, et al. Ortho-Hydroxyanilides: Slow-Acting, Selective Histone Deacetylase 1/2 Inhibitors Suitable for Photocaging Applications. ACS Pharmacol Transl Sci. 2025;8 (12) :4385-4398. 

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  HDAC1; HDAC2; HDAC3; HDAC6

• CAS Number :

  [1013620-98-8]