2DG-ODDA

• Description :

  2DG-ODDA is a 2-deoxyglucose (2-DG) (HY-13966) derivative with potent antitumor activity. 2DG-ODDA induces apoptosis, and reduces ATP production. 2DG-ODDA is taken up through both fatty acid and glucose transporters and is cleaved by α-Mannosidase (HY-P2950), releases 2DG to inhibit N-glycosylation and disrupt cellular metabolism. 2DG-ODDA inhibits tumor growth in a 4T1 mouse model. 2DG-ODDA can be used for the research of triple-negative breast cancer (TNBC) [1].

• UNSPSC :

  12352005

• Target :

  Apoptosis

• Related Pathways :

  Apoptosis

• Field of Research :

  Cancer

• Smiles :

  O=C(N[C@H](CO[C@H]1O[C@H](CO)[C@@H](O)[C@@H](O)C1)C(OC)=O)CCCCCCCCCCCCCCCCC(O)=O

• Molecular Formula :

  C28H51NO10

• Molecular Weight :

  561.71

• References & Citations :

  [1]Jeon S, et al. Exploiting Metabolic Vulnerabilities in Cancer with a Dual-Transporter-Targeted 2-Deoxyglucose Analogue for Low-Dose, Potent Antitumor Activity. J Am Chem Soc. 2025;147 (47) :43267-43272.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported