OPN-9643

CAT: 0804-HY-179559Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-179559Size:1 Each
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Description
OPN-9643 is a covalent inhibitor targeting the central palmitate binding pocket of TEADs with an IC50 of 15 nM, preventing autopalmitoylation and reducing TEAD-driven luciferase activity and canonical TEAD targets, CTGF and CYR61. OPN-9643 can be used for the research of cancer, such as melanoma[1].
CAS Number
[2866423-06-3]
UNSPSC
12352005
Target
YAP
Related Pathways
Stem Cell/Wnt
Field of Research
Cancer
Smiles
C=CC(N1CC2=C(C=CC(OC3=CC=C(C(F)(F)F)C=C3)=C2)CC1)=O
Molecular Formula
C19H16F3NO2
Molecular Weight
347.33
References & Citations
[1]Ott CA, et al. Targeting TAZ-TEAD in minimal residual disease enhances the duration of targeted therapy in melanoma models. Nat Commun. 2025;16 (1) :9655. Published 2025 Nov 5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TEAD

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