Products for Research Use Only
RegisterLogin

MC3817

CAT: 0804-HY-179409Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-179409Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
MC3817 is a selective DNMT1 inhibitor. MC3817 inhibits DNMT1 and DNMT3A/3L with IC50s of 0.044 μM and > 10μM, respectively. MC3817 inhibits P53-dependent cancer cell proliferation, induces apoptosis and DNA damage MC3817 elevates cleaved Caspase 3, P53, and γH2AX. MC3817 can be used in non-small cell lung cancer, colon cancer, cervical cancer, triple-negative breast cancer and histiocytic lymphoma research[1].
UNSPSC
12352005
Target
Apoptosis; Caspase; DNA Methyltransferase; DNA/RNA Synthesis; MDM-2/p53
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Smiles
O=C(NC1=CC(CN(C)C)=CC(NC2=NC(N)=NC(C)=C2)=C1)C3=CC(CN(C)C)=CC(NC4=C5C=CC=CC5=NC=C4)=C3.Cl.Cl.Cl.Cl
Molecular Formula
C33H41Cl4N9O
Molecular Weight
721.55
References & Citations
[1]Zwergel C, et al. Quinoline-Based DNA Methyltransferase Inhibitors Featuring Basic Side Chains: Design, Synthesis, and Insight in Biochemical and Anticancer Cell Properties. J Med Chem. 2025 Nov 27;68 (22) :23886-23909.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
DNMT1; DNMT3

Related Products

CatalogName
HY-P11060MC38 SLP Adpgk
HY-P11059MC38 SLP Reps1

Alternative Products

CatalogName
GTR19274262-01MC3817

Popular Products