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HDAC6 ligand-7

CAT: 0804-HY-179227Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179227Size:1 Each
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Description
HDAC6 ligand-7 (Compound 16a) is a positron emission tomography (PET) tracer for the deacetylase 6 (HDAC6) enzyme with a Kd value of 1.66 nM. HDAC6 ligand-7 exhibits excellent HDAC6 inhibitory activity, with IC50 values of 2.7 and 3.7 nM for hHDAC6 and mHDAC6, respectively, and has high selectivity for HDAC1/4/7/8. HDAC6 ligand-7 after being radioactively labeled with fluorine-18, [¹⁸F]HDAC6 ligand-7 shows varying degrees of radioactive uptake in PET, which can reflect the specific binding to HDAC6. HDAC6 ligand-7 can be used for the study of HDAC6 imaging[1].
UNSPSC
12352005
Target
HDAC
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Neurological Disease
Smiles
O=C(NO)C1=CC=C(CN2N=C(C)C=C2C3=NC(F)=CC=C3)C=C1
Molecular Formula
C17H15FN4O2
Molecular Weight
326.33
References & Citations
[1]Yamasaki T, et al. Discovery of Pyrazole-Based Positron Emission Tomography Agent that Maps Histone Deacetylase 6 (HDAC6) in the Nonhuman Primate Brain. J Med Chem. 2025 Nov 13;68 (21) :23375-23388.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC4; HDAC6; HDAC7; HDAC8

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