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MA203

CAT: 0804-HY-179157Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179157Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MA203 is a highly efficient and selective PROTAC degrader targeting CHK1. MA203 accelerates CRBN-dependent proteasomal degradation of CHK1 in solid tumor-derived cells and acute leukemia cells. MA203 induces DNA replication stress. MA203 blocks cell cycle progression and triggers tumor cell apoptosis. MA203 does not damage healthy differentiated and primitive hematopoietic cells, stromal cells, and retinal epithelial cells. MA203 can be used for the study of CHK1-dependent cancers[1].
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase; Checkpoint Kinase (Chk) ; DNA/RNA Synthesis; PROTACs
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; PROTAC
Field of Research
Cancer
Smiles
O=C1CCC(N2C(C(C=CC=C3NCCCCCCCNC(C4=CC(OC[C@H]5OCCNC5)=C(NC(NC6=CN=C(C)C=N6)=O)C=C4)=O)=C3C2=O)=O)C(N1)=O
Molecular Formula
C38H45N9O8
Molecular Weight
755.82
References & Citations
[1]Ashry R, et al. Identification of a Proteolysis-Targeting-Chimera that Addresses Activated Checkpoint Kinase-1 Reveals its Non-Catalytic Functions in Tumor Cells. Angew Chem Int Ed Engl. 2025 Oct 17:e202514788.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bax; Bcl-xL; Chk1

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