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ZC9

CAT: 0804-HY-179123Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179123Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ZC9 is a novel androgen receptor (AR) degrader. ZC9 directly binds to AR and inhibits Dihydrotestosterone-induced nuclear translocation of AR. ZC9 promotes AR degradation via the ubiquitin-proteasome system and suppresses AR transcriptional activity. ZC9 significantly decreases the mRNA levels of other AR downstream genes, including PSA, TMPRSS2, and PMEPA1. ZC9 promotes Apoptosis. ZC9 exhibits anticancer activity against prostate cancer[1].
CAS Number
2757513-79-2
UNSPSC
12352005
Target
Androgen Receptor; Apoptosis
Related Pathways
Apoptosis; Vitamin D Related/Nuclear Receptor
Field of Research
Cancer
Smiles
O=C(C1=CC=C(C=C(OCC2=C(C)ON=C2C)C=C3)C3=C1)NC4=NC(C5=CC=CS5)=CS4
Molecular Formula
C24H19N3O3S2
Molecular Weight
461.56
References & Citations
[1]Ji Y, et al. Cell-ELISA-Based High-Throughput Screening Leads to the Discovery of Androgen Receptor Degraders to Conquer Castration-Resistant Prostate Cancer. FASEB J. 2025 Oct 31;39 (20) :e71150.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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