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UR241-2

CAT: 0804-HY-179095Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179095Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
UR241-2 is an IRAK4 inhibitor. UR241-2 suppresses IL-1–induced IRAK1/4 signaling, NF-κβ activation, and phosphorylation of p65 and p38. UR241-2 selectively inhibits leukemia stem cell clonogenicity. UR241-2 can serve as a ligand for target proteins for PROTAC, facilitating the development and design of PROTAC degraders for IRAK4. UR241-2 can be used in the research of acute myeloid leukemia[1].
CAS Number
2597345-07-6
UNSPSC
12352005
Target
IRAK; Ligands for Target Protein for PROTAC; NF-κB; p38 MAPK
Related Pathways
Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; PROTAC
Field of Research
Cancer
Smiles
COC1=CC(N2CCNCC2)=CC=C1NC(C3=CC=CC(C4=NNC=C4)=N3)=O
Molecular Formula
C20H22N6O2
Molecular Weight
378.43
References & Citations
[1]Khazan N, et al. PSP-0119: Targeted IRAK4 Degradation as a Novel Therapeutic Strategy for FLT3-Mutant AML. bioRxiv [Preprint]. 2025 Oct 2:2025.09.30.679569.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IRAK1; IRAK4

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