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TBS6b

CAT: 0804-HY-179035Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-179035Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TBS6b is a potent and selective ACKR3 molecular glue degrader. TBS6b degrades ACKR3 via the ubiquitin-proteasome pathway. TBS6b inhibits hepatocellular carcinoma cell proliferation, migration, and invasion. TBS6b is relevant to hepatocellular carcinoma (HCC) research[1].
UNSPSC
12352005
Target
CXCR; Molecular Glues
Related Pathways
GPCR/G Protein; Immunology/Inflammation; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
COC1=C(C(OC)=C2C(C=C(OC2=C1)C3=CC=C(C=C3)OCCCN4C(C)=NC5=C4C=CC=C5)=O)OC
Molecular Formula
C29H28N2O6
Molecular Weight
500.54
References & Citations
[1]Jiang X, et al. Binding and ubiquitination-mediated degradation of ACKR3 by the novel Scutellarein derivative TBS6b potently suppresses hepatocellular carcinoma. Bioorg Chem. Published online October 6, 2025.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CXCR7

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