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PGK1-IN-2

CAT: 0804-HY-178989Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178989Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PGK1-IN-2 (Compound 60) is a PGK1 inhibitor with an IC50 of 8.24 μM. PGK1-IN-2 demonstrates a significant ability to inhibit the proliferation of osteosarcoma cells. PGK1-IN-2 interferes with the glycolytic pathway of tumor cells by inhibiting PGK1. PGK1-IN-2 inhibits cell migration and invasion, and induces cell S phase and G2-M phase cycle arrest. PGK1-IN-2 may kill cells by inducing cuproptosis. PGK1-IN-2 shows a significant anti-tumor effect in the MNNG-HOS osteosarcoma xenograft mouse model. PGK1-IN-2 can be used for the study of osteosarcoma[1].
CAS Number
3054148-68-1
UNSPSC
12352005
Target
Cuproptosis; Phosphoglycerate Kinase (PGK)
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
COCCCCNC(C1=NC(C2N(C3=NC=CC=C3OC)C(CS2)=O)=CC=C1)=O
Molecular Formula
C20H24N4O4S
Molecular Weight
416.49
References & Citations
[1]Chen X, et al. Thiazolidinones as Potential PGK1 Inhibitors for Treatment of Osteosarcoma Growth and Metastasis. J Med Chem. 2025 Nov 13;68 (21) :22216-22245.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PGK1

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