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YL6113

CAT: 0804-HY-178976Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178976Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
YL6113 is a potent and selective dual inhibitor of metallo-β-lactamases (MBLs) and serine-β-lactamases (SBLs). YL6113 shows inhibitory effect to MBLs, such as NDm-1, VIM-2, IMP-1, with IC50 values of 0.25, 27.16 and 3.55 μM. YL6113 shows inhibitory effect to SBLs, such as KPC-2, AmpC, OXA-48, with IC50 values of 0.2, 34.1 and 1.31 μM. YL6113 enhances the antibacterial efficacy of Meropenem against carbapenem-resistant Gram-negative bacteria. YL6113 can be used for the research of infection[1].
UNSPSC
12352005
Target
Beta-lactamase
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
NCC1=CC=C(C=C1)C2=CN(N=N2)CC3=CC=C4OCB(OC4=C3C(O)=O)O.Cl
Molecular Formula
C18H18BClN4O5
Molecular Weight
416.62
References & Citations
[1]Yang ZB, et al. Structural Optimization of Bicyclic Oxo-Boronates as Dual Metallo- and Serine-β-Lactamase Inhibitors. J Med Chem. 2025 Oct 23;68 (20) :21807-21828.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Metallo-β-lactamase (MBL) ; Serine β-lactamase (SBL)

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