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Hck-IN-3

CAT: 0804-HY-178950Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178950Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Hck-IN-3 is an orally effective inhibitor targeting HCK (KD = 3.92 μM) . Hck-IN-3 can inhibit the release of NO. Hck-IN-3 has an IC50 of 6.52 μM in RAW264.7 cells. Hck-IN-3 can inhibit the release of TNF-α, IL-6, and IL-1β in a concentration dependent manner. Hck-IN-3 downregulates the protein expression of NLRP3, ASC, pro-caspase-1, and pro-IL-1β in a concentration dependent manner. Hck-IN-3 can be used for research on acute non traumatic inflammatory conditions[1].
UNSPSC
12352005
Target
Caspase; Interleukin Related; NOD-like Receptor (NLR) ; Src; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation; Protein Tyrosine Kinase/RTK
Field of Research
Inflammation/Immunology
Smiles
COC1=C(OC)C=C(C2=CC(C=CC(OC)=C3OCC4=CC=C(NC(OC(C)(C)C)=O)C=C4)=C3C=[N+]2CC5)C5=C1.[Br-]
Molecular Formula
C32H35BrN2O6
Molecular Weight
623.53
References & Citations
[1]Fan T, et al. Design and synthesis of protoberberine analogues to alleviate LPS-induced acute lung injury by targeting HCK and blocking the HCK-NLRP3 axis. Eur J Med Chem. 2025 Oct 8;302 (Pt 1) :118252.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Caspase 1; Hck; IL-1; IL-6; NLRP3

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