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MKP10241

CAT: 0804-HY-178780Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178780Size:1 Each
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Description
MKP10241 is an orally active GPR119 agonist. MKP10241 elevates cAMP levels in the GPR119 expressing cell line (EC50: 3.7 nM) . MKP10241 reduces blood glucose levels and HbA1c in acute models and a chronic diabetic mouse model. MKP10241 also demonstrates excellent preclinical efficacy in acute as well as chronic rodent models of obesity, and MASH[1].
CAS Number
2137977-29-6
UNSPSC
12352005
Target
GPR119
Related Pathways
GPCR/G Protein; Neuronal Signaling
Field of Research
Metabolic Disease
Smiles
C[C@@H](C1CCN(CC1)C2=NC=C(C=N2)CC)OC(S3)=NN4C3=NC(C5=CC=C(C=C5F)S(C)(=O)=O)=C4
Molecular Formula
C24H27FN6O3S2
Molecular Weight
530.64
References & Citations
[1]Rai SK, et al. Discovery of MKP10241, a Novel Small Molecule Targeting the GPR119/Incretin Axis to Treat Metabolic Disorders. J Med Chem. 2025 Oct 7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Deziglipel
CAS Number2137977-29-6
PubChem CID131984581
IUPAC Name2-[(1S)-1-[1-(5-ethylpyrimidin-2-yl)piperidin-4-yl]ethoxy]-6-(2-fluoro-4-methylsulfonylphenyl)imidazo[2,1-b][1,3,4]thiadiazole
Molecular FormulaC24H27FN6O3S2
Molecular Weight530.6
XLogP4.6
Topological Polar Surface Area139
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count10
Rotatable Bond Count7
Heavy Atom Count36
Formal Charge0
Complexity834
SMILES
CCC1=CN=C(N=C1)N2CCC(CC2)[C@H](C)OC3=NN4C=C(N=C4S3)C5=C(C=C(C=C5)S(=O)(=O)C)F
InChI
InChI=1S/C24H27FN6O3S2/c1-4-16-12-26-22(27-13-16)30-9-7-17(8-10-30)15(2)34-24-29-31-14-21(28-23(31)35-24)19-6-5-18(11-20(19)25)36(3,32)33/h5-6,11-15,17H,4,7-10H2,1-3H3/t15-/m0/s1
InChIKey
UUMBXZTUKTTYMG-HNNXBMFYSA-N
Chemical Structure
2D Structure
2D structure of Deziglipel
CAS: 2137977-29-6
CID: 131984581
Formula: C24H27FN6O3S2
MW: 530.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight530.6
XLogP34.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count10
Rotatable Bond Count7
Exact Mass530.15700925
Monoisotopic Mass530.15700925
Topological Polar Surface Area139 Ų
Heavy Atom Count36
Formal Charge0
Complexity834
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
C21571-5mgMKP10241

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