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DCLK1-IN-6

CAT: 0804-HY-178776Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178776Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
DCLK1-IN-6 (Compound 12n) is a Doublecortin-like kinase 1 (DCLK1) inhibitor with an IC50 of 58 nM. DCLK1-IN-6 significantly inhibits DCLK1 enzyme activity and its mediated inflammatory pathway. DCLK1-IN-6 has remarkable anti-inflammatory activity and significantly alleviates symptoms in acute lung injury (ALI) and sepsis mouse models. DCLK1-IN-6 can be used for acute inflammation diseases research[1].
UNSPSC
12352005
Target
IKK; Interleukin Related; NF-κB; Ser/Thr Protease; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Inflammation/Immunology
Smiles
CN(C1=NC(NC2=C(C=C(C=C2)C(N3CCC4(CC3)CCNCC4)=O)OC)=NC=C1N(C5=O)C)C6=C5C=CC=C6
Molecular Formula
C30H35N7O3
Molecular Weight
541.64
References & Citations
[1]Wu S, et al. Discovery of Benzodiazepinepyrimidine Scaffold Derivatives as Potent Doublecortin-Like Kinase 1 (DCLK1) Inhibitors for the Treatment of Acute Inflammatory Diseases. J Med Chem. 2025 Oct 23;68 (20) :21560-21576.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IKK-β; IL-6

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