Products for Research Use Only
RegisterLogin

MS6076

CAT: 0804-HY-178749Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-178749Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
MS6076 is a mitochondrial protease ClpP agonist. MS6076 specifically activates the ClpP protease in the mitochondrial matrix, significantly disrupting mitochondrial Electron Transport Chain (ETC) function by accelerating the degradation of unfolded proteins. MS6076 exhibits potent cytotoxicity against a variety of breast cancer cell lines, including triple-negative breast cancer cells (MDA-MB-468, MDA-MB-231) and other subtypes (SK-BR-3, MCF-7, BT-474) . MS6076 can be used for the study of breast cancer[1].
Target
ClpP; Mitochondrial Metabolism
Related Pathways
Cell Cycle/DNA Damage; Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C1N(C2=NCCN2C3=C1CN(CC4=CC(C#N)=CC=C4)CC3)CC5=CC=C(C=C5OCCN)C(F)(F)F
Molecular Formula
C27H27F3N6O2
Molecular Weight
524.54
References & Citations
[1]Xu Z, et al. Targeting the Mitochondrial Protease ClpP for Anticancer Therapy. J Med Chem. 2025 Oct 23;68 (20) :21377-21393.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Related Products

CatalogName
HY-141796-01MS67

Alternative Products

CatalogName
GTR19273372-01MS6076

Popular Products