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BION106

CAT: 0804-HY-178728Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178728Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BION106 is a dihydrofolate reductasethymidylate synthase (DHFR-TS) PROTAC degrader. BION106 exhibits extremely strong anti-malarial activity with a Ki and toxicity of 2.68 nM and 0.2 μM against Plasmodium falciparum, and > 100 μM and 44.2 μM in mammalian cells. BION106 can be used for the study of antimalarial parasites (Pink: DHFR-TS ligand ; Blue: Idasanutlin ligand (HY-153007) ; Black: Linker (HY-W021401) ).
CAS Number
3077918-44-3
UNSPSC
12352005
Target
Dihydrofolate reductase (DHFR) ; Parasite; PROTACs
Related Pathways
Anti-infection; Metabolic Enzyme/Protease; PROTAC
Field of Research
Infection
Smiles
N#C[C@@]1(C2=C(C=C(C=C2)Cl)F)[C@@H](C3=C(C(Cl)=CC=C3)F)[C@@H](N[C@H]1CC(C)(C)C)C(NC4=C(C=C(C=C4)C(NCCOCCOCCOCCNC(CCC5=C(C=CC=C5)OCCCOC6=C(N)N=C(N)N=C6CC)=O)=O)OC)=O
Molecular Formula
C57H69Cl2F2N9O9
Molecular Weight
1133.12
References & Citations
[1]Nitipol SRIMONGKOLPITHAK, et al. HYBRID MOLECULES BETWEEN PYRIMIDINE DERIVATIVES AND IDASANUTLIN FIELD OF INVENTION. WO2025053796A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
GTR19275169-01BION106

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