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MyD88-IN-4

CAT: 0804-HY-178690Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178690Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MyD88-IN-4 is a MyD88 inhibitor. MyD88-IN-4 exerts antiviral effects by up-regulating IFN-β, and anti-inflammatory effects by inhibiting pro-inflammatory cytokine production. MyD88-IN-4 prevents MyD88 homodimer formation and its interaction with IRF3/IRF7. MyD88-IN-4 demonstrates efficacy against encephalitic alphavirus infections by reducing viral replication and improving survival in VEEV TC-83-infected mouse models. MyD88-IN-4 can be used for the study of alphavirus infections, bacterial toxin-related diseases, and sepsis[1].
CAS Number
1801552-15-7
UNSPSC
12352005
Target
IFNAR; MyD88
Related Pathways
Immunology/Inflammation
Field of Research
Infection; Inflammation/Immunology
Smiles
O=C(N1CCCC1)[C@H](C(C)C)N(CCCC2=CC=CC=C2)C([C@@H]3CC[C@H](CC3)C(N(CCCC4=CC=CC=C4)[C@@H](C(C)C)C(N5CCCC5)=O)=O)=O
Molecular Formula
C44H64N4O4
Molecular Weight
713.00
References & Citations
[1]Saikh, K. U., et al. A Small Molecule Inhibitor of MyD88 for Therapeutic Treatment Against Alphavirus and Staphylococcal Enterotoxin Infections and Toxin Exposure. International Publication No.: WO 2015/191111 A2. World Intellectual Property Organization (WIPO) . 17 December 2015.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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