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Antileishmanial agent-36

CAT: 0804-HY-178456Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178456Size:1 Each
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Description
Antileishmanial agent-36 (compound 4f) is an indole-dihydropyrimidinone derivative with anti-leishmanial activity. Antileishmanial agent-36 induces reactive oxygen species (ROS) -mediated mitochondrial dysfunction and apoptosis. Antileishmanial agent-36 exhibits potent activity against L. donovani (IC50 =4.54 μM) with low cytotoxicity against J774.1 macrophage. Antileishmanial agent-36 clears the parasite burden in a visceral leishmaniasis (VL) model. Antileishmanial agent-36 can be used for VL research[1].
CAS Number
3086122-36-0
UNSPSC
12352005
Target
Apoptosis; Parasite; Reactive Oxygen Species (ROS)
Related Pathways
Anti-infection; Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Field of Research
Infection
Smiles
O=C1NC(C)=C(C(C2=CC=C(N(C)C)C=C2)N1)C(NCCC3=CNC4=C3C=CC=C4)=O
Molecular Formula
C24H27N5O2
Molecular Weight
417.50
References & Citations
[1]Mishra G, et al. Exploring indole-dihydropyrimidinone derivatives: Design, synthesis, biological assessment, SAR analysis, and evaluation of mode of action in experimental visceral leishmaniasis. Eur J Med Chem. 2025 Sep 5;293:117667.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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