MW073

CAT: 0804-HY-178323Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-178323Size:1 Each

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Description

MW073 is a highly selective and orally active 5-HT2BR antagonist (IC50 =70 nM) . MW073 exerts its effects by concentration-dependently inhibiting receptor activity and β-arrestin-1 recruitment. MW073 ameliorates synaptic plasticity and behavioral deficits, including aggression, in Alzheimer’s disease (AD) mouse models. MW073 can be used for Alzheimer’s disease (AD) research[1][2].

CAS Number

3048608-87-0

UNSPSC

12352005

Target

5-HT Receptor; Arrestin

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

CN1CCN(CC1)CCNC2=NN=C(C=C2C)C3=CC=C4C=CC=CC4=C3

Molecular Formula

C22H27N5

Molecular Weight

361.48

References & Citations

[1]Roy SM, et al. Optimized 5-HT2b inhibitors for neuropsychiatric syndromes with cognitive dysfunction. Alzheimers Dement (N Y) . 2025 Mar 27;11 (1) :e70073. |[2]Acquarone E, et al. The Highly Selective 5-HT2B Receptor Antagonist MW073 Mitigates Aggressive Behavior in an Alzheimer’s Disease Mouse Model. bioRxiv. 2025.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

5-HT2 Receptor

MW073

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