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KT53

CAT: 0804-HY-178261Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178261Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KT53 is a highly active, selective, and cell penetrable GSTO1 inhibitor. KT53 can effectively inhibit GSTO1 activity in MDA-MB-435 (IC50 = 35 nM) cells. KT53 significantly enhances the killing effect of cisplatin on MDA-MB-435 cancer cells. KT53 can be used for cancer research[1].
CAS Number
1338494-49-7
UNSPSC
12352005
Target
Glutathione S-transferase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Smiles
O=C(C(N(C1=CC(F)=CC=C1)C(CCl)=O)C2=NC=CC=C2)NC3CCCCC3
Molecular Formula
C21H23ClFN3O2
Molecular Weight
403.88
References & Citations
[1]Tsuboi K, et al. Potent and selective inhibitors of glutathione S-transferase omega 1 that impair cancer drug resistance. J Am Chem Soc. 2011 Oct 19;133 (41) :16605-16.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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