Morindone

• Description :

  Morindone is an anthraquinone found in Morinda citrifolia L. Morindone can inhibit cancer cells proliferation, induce apoptosis and cause G1 phase arrest. Morindone can inhibit activities of DNA polymerase and downregulate mutated TP53 and KRAS gene expression. Morindone can be used for the research of cancer, such as colon cancer[1][2].

• CAS Number :

  [478-29-5]

• UNSPSC :

  12352005

• Target :

  Apoptosis; DNA/RNA Synthesis

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Smiles :

  O=C1C2=CC=C(C)C(O)=C2C(C3=CC=C(C(O)=C13)O)=O

• Molecular Formula :

  C15H10O5

• Molecular Weight :

  270.24

• References & Citations :

  [1]Chee CW, et al. Morindone as a potential therapeutic compound targeting TP53 and KRAS mutations in colorectal cancer cells. Chem Biol Interact. 2024 Apr 1;392:110928. |[2]Cheok Wui Chee, et al. Morindone as a potential therapeutic compound targeting TP53 and KRAS mutations in colorectal cancer cells, Chemico-Biological Interactions, Volume 392, 2024, 110928, ISSN 0009-2797.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Natural Products

• Clinical Information :

  No Development Reported