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ARUK2010489

CAT: 0804-HY-178171Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178171Size:1 Each
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Description
ARUK2010489 (Compound 23) is a potent, selective and brain-penetrant NUAK1 inhibitor with a pIC50 of 8.7. ARUK2010489 also inhibits CDK2, CDK4 and CDK6 activity, with inhibitory rate of 7%, 39% and 26% at 1 μM. ARUK2010489 can be used for the research of neurological disease, such as Alzheimer’s disease (AD) [1].
UNSPSC
12352005
Target
AMPK; CDK
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; PI3K/Akt/mTOR
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Smiles
CC(N1CCN(C2=CC=C(NC3=NC(OCC4CC4)=C5C(NC=C5)=N3)C=C2)CC1)C
Molecular Formula
C23H30N6O
Molecular Weight
406.52
References & Citations
[1]Gregory G. et al. Development of Purine and Pyrrolopyrimidine Scaffolds as Potent, Selective, and Brain Penetrant NUAK1 Inhibitors ACS Medicinal Chemistry Letters Article ASAP
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2; CDK4; CDK6; NUAK1

Alternative Products

CatalogName
GTR19272706-01ARUK2010489

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