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ZM484

CAT: 0804-HY-178036Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-178036Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ZM484 is a potent dual p53-MDM2/TOP1 inhibitor that exhibits antiproliferative and antitumor activity both in vitro and in vivo. ZM484 effectively upregulates p53 and MDM2 proteins and maintains TOP1 inhibitory activity by the release of camptothecin (CPT) and a potent p53-MDM2 inhibitor. ZM484 induces cell cycle arrest and apoptosis by regulating the expression of key apoptosis- and cycle-related proteins, including caspase-3, Bcl-2, and Cyclin B1. ZM484 can be used for colorectal cancer research[1].
UNSPSC
12352005
Target
Bcl-2 Family; Caspase; Cyclin G-associated Kinase (GAK) ; MDM-2/p53; Topoisomerase
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C1C2=C(C=C3C4=NC5=CC=CC=C5C=C4CN31)[C@](OC(OCCSSCCOC(CCOCCOCCOCCOCCNC(C6=CC(OC)=C(NC([C@@H]([C@@H]([C@]7(C8=C(C=C(C=C8)Cl)F)C#N)C9=CC=CC(Cl)=C9F)N[C@H]7CC(C)(C)C)=O)C=C6)=O)=O)=O)(C(OC2)=O)CC
Molecular Formula
C67H72Cl2F2N6O15S2
Molecular Weight
1374.35
References & Citations
[1]Wang C, et al. Discovery of Novel Drug-Conjugate Molecule ZM484 with Dual p53-MDM2 and TOP1 Inhibition for the Treatment of Colorectal Cancer. J Med Chem. 2025 Sep 25;68 (18) :18988-19001.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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CatalogName
GTR19274013-01ZM484

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