Products for Research Use Only
RegisterLogin

Mcl-1-IN-17

CAT: 0804-HY-178010Size: 1 EachDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-178010Size:1 Each
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
Mcl-1-IN-17 (Compound 25) is an orally active Myeloid Cell Leukemia 1 (Mcl-1) inhibitor with a Ki GI50s of 39 and 105 nM for H929 and A427 cells, respectively) and inhibits cell apoptosis. Mcl-1-IN-17 can be used for hematological and solid cancers research[1].
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family
Related Pathways
Apoptosis
Field of Research
Cancer
Smiles
CC1=C(Cl)C(C)=CC(OCCCC2=C(C(N(C3=CC(OC)=C(OC)C4=C3N(CCCOC5)C(C(N(C)C)=O)=C4)C[C@H]6C)=O)N6C7=C2C=CC(Cl)=C7C(C5=N8)=CN8C)=C1
Molecular Formula
C44H48Cl2N6O6
Molecular Weight
827.79
References & Citations
[1]Tarr JC, et al. Discovery of Macrocyclic Myeloid Cell Leukemia 1 (Mcl-1) Inhibitors that Demonstrate Potent Cellular Efficacy and In Vivo Activity in a Mouse Solid Tumor Xenograft Model. J Med Chem. 2025 Sep 11;68 (17) :18553-18578.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Mcl-1

Related Products

CatalogName
HY-178008Mcl-1-IN-16
HY-162780Mcl-1-IN-19
HY-178910Mcl-1-IN-20
HY-130261Mcl-1 antagonist 1
HY-133015Mcl-1 inhibitor 3
HY-132307-01Mcl-1 inhibitor 6
HY-170763B(-) -Mcl-1 inhibitor 22
HY-170763Mcl-1 inhibitor 22
HY-148899Mcl-1 inhibitor 10
HY-148203Mcl-1 inhibitor 9

Alternative Products

CatalogName
GTR19273362-01Mcl-1-IN-17
T84800-01Mcl-1 inhibitor 17
sc-69839Mcl-1 (MCL-401)
sc-69840Mcl-1 (MCL-2601)
sc-69841Mcl-1 (MCL-1801)
Mab-604030MCL-1
GWB-1118C4Mcl-1, Antibody
391437Mcl-1 discontinued
MBS850948-01MCL-1 Antibody
MBS8001669-01MCL 1 Antibody

Popular Products