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HSN608

CAT: 0804-HY-176937Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176937Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HSN608 is an orally active, potent RET G810 mutant inhibitor. HSN608 inhibits G810C, G810R, G810D. HSN608 induces Apoptosis. HSN608 inhibits the Selpercatinib -resistant RET (G810C) CDX tumors[1].
CAS Number
2234239-90-6
UNSPSC
12352005
Target
Apoptosis; RET
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
O=C(NC1=CC=C(C(C(F)(F)F)=C1)CN2CCN(C)CC2)C3=CC(C#CC4=C5C=CC=NC5=C(N=C4)N)=CN=C3
Molecular Formula
C29H26F3N7O
Molecular Weight
545.56
References & Citations
[1]Khatri U, et al. Targeting RET Solvent-Front Mutants with Alkynyl Nicotinamide-Based Inhibitors. Mol Cancer Ther. 2023 Jun 1;22 (6) :717-725.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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