Products for Research Use Only
RegisterLogin

SW016789

CAT: 0804-HY-176745-01Size: 5 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-176745-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
SW016789 is a hypersecretion-inducer targeting VDAC1. SW016789 can induce insulin hypersecretion and Ca2+ influx in β-cells directly. SW016789 induces a transient endoplasmic reticulum stress response (ER stress), but does not cause beta cell death. SW016789 has reversible and non-apoptotic characteristics. SW016789 can be used for the study of Diabetes mellitus type 2 (T2DM) β-cell dysfunction[1][2].
CAS Number
292613-04-8
UNSPSC
12352005
Target
VDAC
Related Pathways
Membrane Transporter/Ion Channel
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology; Metabolic Disease
Purity
99.85
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
N=C1N(C2=CC=CC=C2N1CC(C3=CC=CS3)O)CC4=CC=CC=C4
Molecular Formula
C20H19N3OS
Molecular Weight
349.45
References & Citations
[1]Roy G, et al. VDAC1 is a target for pharmacologically induced insulin hypersecretion in β cells. Cell Rep. 2025 Jun 24;44 (6) :115834. |[2]Rodrigues-Dos-Santos K et, al. Small Molecule-mediated Insulin Hypersecretion Induces Transient ER Stress Response and Loss of Beta Cell Function. Endocrinology. 2022 Jul 1;163 (7) :bqac081.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
VDAC1

Alternative Products

CatalogName
GTR19263244-01SW016789

Popular Products