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Thalidomide-N-C-piperidine-C7-Br

CAT: 0804-HY-176470Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-176470Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Thalidomide-N-C-piperidine-C7-Br, an E3 ligase ligand-linker conjugate, incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and a linker. Thalidomide-N-C-piperidine-C7-Br can be used in the synthesis of ZS3-046.
UNSPSC
12352005
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Field of Research
Cancer
Smiles
O=C(N1C2CCC(NC2=O)=O)C3=C(NCC4CCN(CCCCCCCBr)CC4)C=CC=C3C1=O
Molecular Formula
C26H35BrN4O4
Molecular Weight
547.48
References & Citations
[1]Chen L, et al. PROTAC-Mediated Degradation of TAF1 Induces Apoptosis in AML Cells and Inhibits Tumor Growth In Vivo. Mol Cancer Ther. 2025 May 16:OF1-OF10.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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