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RP03707

CAT: 0804-HY-176134-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-176134-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RP03707 is a PROTAC based KRASG12D degrader (Red: KRASG12D inhibitor , black: linker, Blue: E3 ligase ligand).
CAS Number
3030493-05-8
UNSPSC
12352005
Target
PROTACs; Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
96.67
Smiles
O=C1NC(CCN1C2=NN(C)C3=C2C=C(F)C(C4CCN(C5CC6(CCN(CC7(COC8=NC9=C(C=NC(C%10=C%11C(C#C)=C(F)C=CC%11=CC(O)=C%10)=C9F)C(N%12C[C@H]%13N[C@H](CC%13)C%12)=N8)CC7)CC6)C5)CC4)=C3)=O
Molecular Formula
C55H58F3N11O4
Molecular Weight
994.12
References & Citations
[1]Ji X, et al. Discovery and Characterization of RP03707: A Highly Potent and Selective KRASG12D PROTAC. J Med Chem. 2025 May 8.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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